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Significant highway drug busts in the United States often involve large-scale trafficking operations on major interstates, resulting in the seizure of hundreds of pounds of narcotics. Recent record-setting, highway-related, or vehicle-based seizures include:

• Largest Fentanyl Bust in DEA History (May 2025): Federal authorities seized over 400 kilograms (880+ lbs) of fentanyl pills and powder, along with other drugs, in a multi-state operation that spanned New Mexico, Arizona, Nevada, Oregon, and Utah.
• South Dakota Meth Bust (August 2025): The South Dakota Highway Patrol seized 207 pounds of crystal meth—worth an estimated $12 million—during a traffic stop on I-90 in Sturgis.
• Illinois Cocaine Seizure (Nov 2025): Over 1,146 pounds of cocaine, worth more than $40 million, were discovered inside a semi-truck on Interstate 80 at the Illinois/Iowa state line.
• Texas Liquid Fentanyl Bust (Nov 2022): A traffic stop in Nueces County, Texas, led to the largest liquid fentanyl seizure in U.S. history.
• Kansas Marijuana/Cocaine Bust (June 2025): A commercial vehicle stop on Interstate 70 in Geary County, Kansas, resulted in the seizure of over 3,200 pounds of marijuana and 260 pounds of cocaine, valued at $4 million.
• Ohio I-70 Meth Bust (August 2024): A commercial vehicle stop in Madison County, Ohio, resulted in the seizure of 300 pounds of methamphetamine, 17.6 pounds of cocaine, and 30 pounds of marijuana, with a street value of $14.6 million.
• Michigan Cocaine Seizure (Oct 2025): A traffic stop in Port Huron, Michigan, led to the seizure of 370 pounds of cocaine, valued at $16.5 million, marking a record for the local drug task force.
• Wyoming Interstate 80 Bust (May 2019): A traffic stop on I-80 in Laramie County resulted in the seizure of 46 pounds of methamphetamine, 2.5 kilograms of cocaine, 1 kg of fentanyl, and 3 kg of heroin. 

Key Trends in Highway Trafficking:

• Interstate Focus: I-70, I-80, and I-90 are frequently identified as major corridors for transporting large quantities of drugs.
• Hidden Compartments: Traffickers often use sophisticated hidden compartments in commercial vehicles, such as in refrigerated trailers or within legitimate cargo.
• International Connections: Many of these busts involve links to transnational cartels, such as the Sinaloa Cartel, transporting drugs from the U.S.-Mexico border to cities across the U.S..